Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1_controls	AD-GWAS	7.59e-01	9.17e-01	4.06e-01	1.42e-01
AD-GWAS	ADSP_NewLabels_10K_UKBAC1_controls	5.01e-02	4.59e-01	5.94e-02	4.48e-04



Evaluating how well ADSP_NewLabels_10K_UKBAC1_controls genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1_controls	AD-GWAS	0.62	-0.20	0.15	0.13	2.17
AD-GWAS	ADSP_NewLabels_10K_UKBAC1_controls	0.60	-0.02	0.59	0.11	2.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_UKBAC1_controls	AD-GWAS	0.00	-0.51	-0.48	-0.24	0.55
AD-GWAS	ADSP_NewLabels_10K_UKBAC1_controls	0.00	-0.43	-0.22	-0.21	1.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_10K_UKBAC1_controls	73	73	
AD-GWAS	25	24	HLA -DRB1