Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_10K_CohortAC1 Exclusive	AD-Familial	5.18e-01	6.71e-02	1.01e-01	2.43e-05
AD-Familial Exclusive	ADSP_NewLabels_10K_CohortAC1	5.36e-02	3.77e-01	4.03e-53	9.83e-16
ADSP_NewLabels_10K_CohortAC1 Exclusive	AD-Familial Exclusive	7.72e-01	6.97e-02	6.75e-02	5.45e-06
AD-Familial Exclusive	ADSP_NewLabels_10K_CohortAC1 Exclusive	7.25e-02	4.76e-01	1.13e-49	3.52e-15
ADSP_NewLabels_10K_CohortAC1 Exclusive	Overlap	7.54e-01	1.49e-01	2.58e-01	4.05e-01
AD-Familial Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.44e-05	6.97e-04	1.60e-08	3.18e-21



Evaluating how well ADSP_NewLabels_10K_CohortAC1 genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_CohortAC1 Exclusive	AD-Familial	0.81	1.48	2.95	1.62	4.45
AD-Familial Exclusive	ADSP_NewLabels_10K_CohortAC1	0.59	1.81	1.69	0.66	8.20
ADSP_NewLabels_10K_CohortAC1 Exclusive	AD-Familial Exclusive	0.84	1.22	2.54	1.80	4.28
AD-Familial Exclusive	ADSP_NewLabels_10K_CohortAC1 Exclusive	0.59	1.68	1.47	0.52	8.42
ADSP_NewLabels_10K_CohortAC1 Exclusive	Overlap	0.63	1.20	0.99	1.45	0.63
AD-Familial Exclusive	Overlap	1.00	5.67	2.84	2.84	2.48
Overlap	Exclusives	0.60	0.21	3.88	0.68	9.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_10K_CohortAC1 Exclusive	AD-Familial	0.00	-1.52	1.08	-0.77	1.43
AD-Familial Exclusive	ADSP_NewLabels_10K_CohortAC1	0.05	2.27	3.77	1.41	8.52
ADSP_NewLabels_10K_CohortAC1 Exclusive	AD-Familial Exclusive	0.00	-1.57	1.96	-0.74	4.36
AD-Familial Exclusive	ADSP_NewLabels_10K_CohortAC1 Exclusive	0.05	1.73	2.01	0.48	6.91
ADSP_NewLabels_10K_CohortAC1 Exclusive	Overlap	0.00	0.88	-0.15	1.08	-0.13
AD-Familial Exclusive	Overlap	0.42	9355.02	2563.30	1118.31	481.07
Overlap	Exclusives	0.05	0.06	5.32	0.52	9.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_10K_CohortAC1 Exclusive	709	703	GBA3;MUC2;MUC19;PNLIPRP2;UGT2A1;TFDP2
AD-Familial Exclusive	12	12	
Overlap	2	2