Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_5K_CohortAC1	AD-Familial	5.23e-01	9.66e-02	1.54e-02	8.00e-04
AD-Familial	ADSP_NewLabels_5K_CohortAC1	1.78e-10	8.47e-01	2.76e-30	1.22e-14



Evaluating how well ADSP_NewLabels_5K_CohortAC1 genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_5K_CohortAC1	AD-Familial	0.76	0.53	1.34	1.06	3.36
AD-Familial	ADSP_NewLabels_5K_CohortAC1	0.59	0.17	0.25	0.42	7.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_5K_CohortAC1	AD-Familial	0.00	-1.58	-0.03	-1.06	0.92
AD-Familial	ADSP_NewLabels_5K_CohortAC1	0.04	-0.21	-0.08	0.27	5.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_5K_CohortAC1	624	620	MUC19;UGT2A1;TFDP2;MUC2
AD-Familial	14	14