Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_NewLabels_5K_CohortAC1 Exclusive	AD-GWAS	4.98e-02	2.64e-01	5.46e-01	6.46e-04
AD-GWAS Exclusive	ADSP_NewLabels_5K_CohortAC1	2.69e-07	4.98e-02	2.09e-05	2.67e-11
ADSP_NewLabels_5K_CohortAC1 Exclusive	AD-GWAS Exclusive	9.97e-02	3.31e-01	5.22e-01	2.84e-03
AD-GWAS Exclusive	ADSP_NewLabels_5K_CohortAC1 Exclusive	8.91e-07	4.13e-02	1.55e-06	1.62e-11
ADSP_NewLabels_5K_CohortAC1 Exclusive	Overlap	5.40e-01	4.17e-01	5.27e-01	2.50e-01
AD-GWAS Exclusive	Overlap	4.17e-01	1.49e-01	1.54e-01	8.35e-02
Overlap	Exclusives	4.10e-08	6.65e-04	6.30e-09	7.57e-09



Evaluating how well ADSP_NewLabels_5K_CohortAC1 genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_5K_CohortAC1 Exclusive	AD-GWAS	0.67	-0.31	0.66	0.20	3.16
AD-GWAS Exclusive	ADSP_NewLabels_5K_CohortAC1	0.57	-0.31	-1.69	-0.35	5.99
ADSP_NewLabels_5K_CohortAC1 Exclusive	AD-GWAS Exclusive	0.65	-0.60	0.52	-0.32	2.78
AD-GWAS Exclusive	ADSP_NewLabels_5K_CohortAC1 Exclusive	0.56	-0.23	-1.43	-0.38	5.27
ADSP_NewLabels_5K_CohortAC1 Exclusive	Overlap	0.80	1.87	1.54	2.04	1.42
AD-GWAS Exclusive	Overlap	0.86	1.94	1.78	1.71	2.30
Overlap	Exclusives	0.59	0.21	2.59	0.56	7.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_NewLabels_5K_CohortAC1 Exclusive	AD-GWAS	0.00	-1.07	-0.09	-0.43	0.31
AD-GWAS Exclusive	ADSP_NewLabels_5K_CohortAC1	0.04	-0.20	-1.04	-0.26	3.87
ADSP_NewLabels_5K_CohortAC1 Exclusive	AD-GWAS Exclusive	0.00	-1.60	-0.29	-1.11	0.39
AD-GWAS Exclusive	ADSP_NewLabels_5K_CohortAC1 Exclusive	0.04	-0.05	-1.10	-0.24	3.07
ADSP_NewLabels_5K_CohortAC1 Exclusive	Overlap	0.00	10.31	0.42	6.40	0.70
AD-GWAS Exclusive	Overlap	0.00	18.92	6.81	4.79	2.78
Overlap	Exclusives	0.05	1.14	9.89	1.37	12.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_NewLabels_5K_CohortAC1 Exclusive	622	618	UGT2A1;MUC2;MUC19;TFDP2
AD-GWAS Exclusive	23	22	HLA -DRB1
Overlap	2	2