Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_5K_EPI	14GS	4.88e-01	5.36e-01	2.46e-01	3.24e-02
14GS	2020_5K_EPI	8.11e-01	2.31e-01	3.20e-04	6.06e-01



Evaluating how well 2020_5K_EPI genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_5K_EPI	14GS	0.68	0.12	0.70	0.61	2.30
14GS	2020_5K_EPI	0.53	2.83	1.58	1.53	0.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_5K_EPI	14GS	0.00	0.57	2.43	0.40	0.33
14GS	2020_5K_EPI	0.00	1.04	0.61	0.83	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_5K_EPI	79	76	RFPL2;TNFSF12-TNFSF13;PRAMEF11
14GS	14	14