Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1	AD-GWAS	7.04e-03	4.37e-04	3.02e-05	3.54e-06
AD-GWAS	ADSP_OldLabels_5K_UKBAC1	2.43e-02	8.48e-02	2.12e-03	5.57e-05



Evaluating how well ADSP_OldLabels_5K_UKBAC1 genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1	AD-GWAS	0.79	2.01	4.51	2.20	5.10
AD-GWAS	ADSP_OldLabels_5K_UKBAC1	0.68	1.40	2.63	1.06	4.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1	AD-GWAS	0.01	1.93	9.23	1.01	5.90
AD-GWAS	ADSP_OldLabels_5K_UKBAC1	0.01	4.52	8.53	4.72	11.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC1	61	61	
AD-GWAS	25	24	HLA -DRB1