Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_controls	AD-GWAS	9.29e-01	1.68e-01	6.30e-01	4.07e-03
AD-GWAS	ADSP_OldLabels_5K_UKBAC1_controls	1.68e-02	2.40e-01	9.35e-01	3.40e-01



Evaluating how well ADSP_OldLabels_5K_UKBAC1_controls genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_controls	AD-GWAS	0.65	0.52	1.11	0.36	2.42
AD-GWAS	ADSP_OldLabels_5K_UKBAC1_controls	0.54	-0.67	-2.43	-0.82	1.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_controls	AD-GWAS	0.00	-0.16	0.62	-0.14	0.51
AD-GWAS	ADSP_OldLabels_5K_UKBAC1_controls	0.00	-0.27	-1.30	-0.39	0.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC1_controls	72	72	
AD-GWAS	25	24	HLA -DRB1