Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_new_clean	14GS	1.64e-01	3.35e-02	3.90e-01	2.35e-03
14GS	2020_new_clean	1.62e-01	6.79e-01	1.13e-02	4.27e-01



Evaluating how well 2020_new_clean genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_new_clean	14GS	0.75	1.20	2.40	0.95	3.40
14GS	2020_new_clean	0.48	0.42	-0.85	-0.01	-0.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_new_clean	14GS	0.00	0.47	1.25	0.16	1.95
14GS	2020_new_clean	0.01	0.32	0.56	0.67	0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_new_clean	103	101	PRAMEF11;TNFSF12-TNFSF13
14GS	14	14