Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_new_clean Exclusive	25GS	5.01e-05	2.24e-05	5.18e-04	1.43e-07
25GS Exclusive	2020_new_clean	2.08e-01	3.99e-01	7.21e-02	3.12e-01
2020_new_clean Exclusive	25GS Exclusive	1.79e-05	1.00e-05	2.83e-04	1.13e-06
25GS Exclusive	2020_new_clean Exclusive	1.91e-01	2.87e-01	5.95e-02	4.49e-01
2020_new_clean Exclusive	Overlap	6.52e-01	9.92e-02	4.00e-01	2.17e-01
25GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	9.59e-03	2.26e-02	1.56e-29	1.29e-02



Evaluating how well 2020_new_clean genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_new_clean Exclusive	25GS	0.81	3.28	5.10	3.00	5.94
25GS Exclusive	2020_new_clean	0.53	1.92	0.95	1.71	0.92
2020_new_clean Exclusive	25GS Exclusive	0.81	3.49	5.25	3.05	4.82
25GS Exclusive	2020_new_clean Exclusive	0.52	1.46	1.13	1.90	0.85
2020_new_clean Exclusive	Overlap	0.87	-0.02	-188478870233802.34	-0.30	1.32
25GS Exclusive	Overlap	1.00	1.39	111424462830387.00	1.68	1.69
Overlap	Exclusives	0.57	174873916649366.00	2.68	2.13	2.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_new_clean Exclusive	25GS	0.01	5.93	11.73	4.71	4.78
25GS Exclusive	2020_new_clean	0.01	5.05	4.86	5.34	5.41
2020_new_clean Exclusive	25GS Exclusive	0.00	6.86	13.00	4.65	6.34
25GS Exclusive	2020_new_clean Exclusive	0.01	5.18	4.55	1.46	2.03
2020_new_clean Exclusive	Overlap	0.00	-0.46	-1616873055503395.00	-0.48	0.59
25GS Exclusive	Overlap	0.02	29.08	32920936630948200.00	35.92	25.12
Overlap	Exclusives	0.01	1357363433888762.25	6.26	5.48	7.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_new_clean Exclusive	102	100	TNFSF12-TNFSF13;PRAMEF11
25GS Exclusive	24	23	HLA -DRB1
Overlap	1	1