Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1	AD-GWAS	6.44e-02	1.09e-02	1.56e-05	7.38e-04
AD-GWAS	ADSP_OldLabels_10K_UKBAC1	6.59e-02	1.69e-01	1.58e-03	5.72e-09



Evaluating how well ADSP_OldLabels_10K_UKBAC1 genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1	AD-GWAS	0.73	1.43	2.50	2.18	4.13
AD-GWAS	ADSP_OldLabels_10K_UKBAC1	0.67	0.85	2.08	1.07	6.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1	AD-GWAS	0.00	0.51	2.10	2.83	3.82
AD-GWAS	ADSP_OldLabels_10K_UKBAC1	0.01	1.53	3.36	2.47	5.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_10K_UKBAC1	120	120	
AD-GWAS	25	24	HLA -DRB1