Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls	AD-GWAS	1.43e-02	5.33e-01	8.41e-01	1.58e-02
AD-GWAS	ADSP_OldLabels_10K_UKBAC1_controls	3.58e-05	8.27e-02	2.93e-02	7.41e-08



Evaluating how well ADSP_OldLabels_10K_UKBAC1_controls genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls	AD-GWAS	0.60	-1.32	-0.11	-0.27	1.64
AD-GWAS	ADSP_OldLabels_10K_UKBAC1_controls	0.57	-0.61	-1.63	-0.35	3.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls	AD-GWAS	0.00	-1.14	-0.57	-0.40	0.00
AD-GWAS	ADSP_OldLabels_10K_UKBAC1_controls	0.01	-0.49	-1.64	-0.29	1.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_10K_UKBAC1_controls	174	174	
AD-GWAS	25	24	HLA -DRB1