Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_cases	AD-GWAS	8.78e-02	2.89e-01	1.88e-03	1.23e-02
AD-GWAS	ADSP_5Kadded2020_UKBAC1_cases	2.83e-01	1.51e-02	4.10e-04	2.94e-08



Evaluating how well ADSP_5Kadded2020_UKBAC1_cases genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_cases	AD-GWAS	0.68	0.37	1.16	1.24	2.85
AD-GWAS	ADSP_5Kadded2020_UKBAC1_cases	0.70	2.50	2.97	2.12	6.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_cases	AD-GWAS	0.00	0.31	0.95	2.05	2.72
AD-GWAS	ADSP_5Kadded2020_UKBAC1_cases	0.01	1.62	2.35	1.11	5.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_5Kadded2020_UKBAC1_cases	69	69	
AD-GWAS	25	24	HLA -DRB1