Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls Exclusive	AD-GWAS	1.12e-01	1.48e-01	1.17e-02	5.77e-03
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls	4.90e-01	1.45e-03	6.62e-08	1.37e-11
ADSP_5Kadded2020_UKBAC1_controls Exclusive	AD-GWAS Exclusive	2.61e-01	2.84e-01	2.46e-02	1.35e-02
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls Exclusive	5.79e-01	9.45e-04	1.67e-07	1.48e-11
ADSP_5Kadded2020_UKBAC1_controls Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AD-GWAS Exclusive	Overlap	4.53e-01	5.10e-01	4.91e-01	5.10e-01
Overlap	Exclusives	3.95e-15	6.25e-17	1.01e-23	3.61e-25



Evaluating how well ADSP_5Kadded2020_UKBAC1_controls genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls Exclusive	AD-GWAS	0.70	1.26	1.96	1.02	3.59
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls	0.66	1.23	4.00	1.66	6.39
ADSP_5Kadded2020_UKBAC1_controls Exclusive	AD-GWAS Exclusive	0.68	0.92	1.93	1.05	3.20
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls Exclusive	0.66	1.04	3.86	1.19	5.87
ADSP_5Kadded2020_UKBAC1_controls Exclusive	Overlap	1.00	1.69	1.81	1.99	1.70
AD-GWAS Exclusive	Overlap	0.71	0.74	0.42	0.47	0.61
Overlap	Exclusives	0.77	1.75	10.46	1.89	13.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls Exclusive	AD-GWAS	0.00	0.50	2.43	2.09	4.23
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls	0.01	0.46	3.16	0.89	2.60
ADSP_5Kadded2020_UKBAC1_controls Exclusive	AD-GWAS Exclusive	0.00	-0.00	1.06	0.75	2.79
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls Exclusive	0.01	0.38	2.49	0.39	2.96
ADSP_5Kadded2020_UKBAC1_controls Exclusive	Overlap	0.01	52.15	57.08	17.52	24.72
AD-GWAS Exclusive	Overlap	0.00	-0.05	-0.29	-0.14	-0.17
Overlap	Exclusives	0.06	12.55	62.94	9.10	61.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_5Kadded2020_UKBAC1_controls Exclusive	136	136	
AD-GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1