Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_10K_clean	14GS	2.72e-01	1.05e-01	1.55e-01	7.12e-03
14GS	2020_10K_clean	3.60e-01	8.74e-02	1.34e-08	7.09e-02



Evaluating how well 2020_10K_clean genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_10K_clean	14GS	0.77	1.32	2.96	1.59	3.44
14GS	2020_10K_clean	0.56	2.86	2.59	2.36	2.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_10K_clean	14GS	0.00	0.66	3.06	0.64	2.98
14GS	2020_10K_clean	0.01	2.95	1.75	1.46	1.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_10K_clean	110	105	;AL162417.1;TNFSF12-TNFSF13;PRAMEF11;RFPL2
14GS	14	14