Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) mu Exclusive 25AD 6.58e-01 5.53e-01 8.32e-01 3.60e-02 25AD Exclusive mu 8.61e-01 1.59e-01 2.56e-02 2.70e-01 mu Exclusive 25AD Exclusive 8.58e-01 4.88e-01 9.24e-01 2.40e-02 25AD Exclusive mu Exclusive 9.58e-01 1.80e-01 2.34e-02 4.32e-01 mu Exclusive Overlap 7.34e-01 7.14e-01 5.50e-01 4.91e-01 25AD Exclusive Overlap 9.92e-02 9.92e-02 9.92e-02 9.92e-02 Overlap Exclusives 6.39e-05 5.25e-05 1.10e-05 6.68e-06 Evaluating how well mu genes are linked to 25AD genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) mu Exclusive 25AD 0.64 0.41 1.32 0.21 2.28 25AD Exclusive mu 0.55 2.35 1.83 1.31 1.20 mu Exclusive 25AD Exclusive 0.64 0.30 1.38 0.34 2.27 25AD Exclusive mu Exclusive 0.54 2.03 1.62 1.31 1.03 mu Exclusive Overlap 0.65 0.29 0.22 0.40 0.54 25AD Exclusive Overlap 1.00 1.61 1.75 2.07 1.67 Overlap Exclusives 0.67 2.03 5.32 2.62 5.05 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) mu Exclusive 25AD 0.00 -0.14 0.96 -0.27 0.11 25AD Exclusive mu 0.00 3.12 2.79 2.26 2.01 mu Exclusive 25AD Exclusive 0.00 -0.19 0.90 -0.15 -0.02 25AD Exclusive mu Exclusive 0.00 0.31 0.19 0.28 0.01 mu Exclusive Overlap 0.00 -0.26 -0.28 -0.22 -0.15 25AD Exclusive Overlap 0.06 137.37 257.17 111.67 85.31 Overlap Exclusives 0.02 14.70 6.76 17.01 33.69 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes mu Exclusive 50 49 AC018755.2 25AD Exclusive 24 23 HLA -DRB1 Overlap 1 1