Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls_cleaned	AD-Familial	4.53e-05	2.32e-06	2.32e-06	3.12e-07
AD-Familial	ADSP_5Kadded2020_UKBAC1_controls_cleaned	4.02e-09	1.55e-11	5.93e-25	1.61e-17



Evaluating how well ADSP_5Kadded2020_UKBAC1_controls_cleaned genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls_cleaned	AD-Familial	0.91	2.93	5.76	2.77	5.51
AD-Familial	ADSP_5Kadded2020_UKBAC1_controls_cleaned	0.73	5.25	8.00	2.55	8.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls_cleaned	AD-Familial	0.01	1.61	20.84	4.17	10.49
AD-Familial	ADSP_5Kadded2020_UKBAC1_controls_cleaned	0.02	3.22	10.65	4.66	8.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_5Kadded2020_UKBAC1_controls_cleaned	124	124	
AD-Familial	14	14