Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	AD-GWAS	9.81e-03	1.22e-02	9.92e-04	9.02e-05
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls_cleaned	1.29e-02	2.94e-05	3.80e-09	5.83e-12
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	AD-GWAS Exclusive	3.04e-02	2.49e-02	3.18e-03	3.27e-04
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	5.91e-03	3.38e-05	5.83e-10	2.50e-11
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AD-GWAS Exclusive	Overlap	5.90e-01	5.90e-01	4.91e-01	3.67e-01
Overlap	Exclusives	1.45e-16	1.73e-17	1.30e-20	2.16e-22



Evaluating how well ADSP_5Kadded2020_UKBAC1_controls_cleaned genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	AD-GWAS	0.75	1.52	3.74	1.98	4.24
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls_cleaned	0.67	2.16	4.78	1.95	7.36
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	AD-GWAS Exclusive	0.74	1.52	2.81	2.02	4.02
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	0.67	2.33	4.79	1.89	6.01
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	Overlap	1.00	1.78	2.02	1.67	1.68
AD-GWAS Exclusive	Overlap	0.71	0.60	0.22	0.38	0.81
Overlap	Exclusives	0.77	1.73	9.46	1.83	11.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	AD-GWAS	0.00	1.31	4.42	2.17	4.40
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls_cleaned	0.01	1.71	4.20	1.27	5.96
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	AD-GWAS Exclusive	0.00	0.40	2.45	1.05	2.47
AD-GWAS Exclusive	ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	0.01	1.73	3.52	0.64	5.61
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	Overlap	0.01	23.71	42.04	30.70	26.56
AD-GWAS Exclusive	Overlap	0.00	-0.16	-0.40	-0.22	-0.09
Overlap	Exclusives	0.05	9.30	56.35	5.95	35.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_5Kadded2020_UKBAC1_controls_cleaned Exclusive	123	123	
AD-GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1