Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	AD-Familial	4.79e-01	2.02e-01	1.12e-02	7.81e-03
AD-Familial	ADSP_OldLabels_10K_UKBAC1_controls_cleaned	7.73e-01	2.45e-01	2.70e-06	3.28e-06



Evaluating how well ADSP_OldLabels_10K_UKBAC1_controls_cleaned genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	AD-Familial	0.76	0.50	1.64	1.23	3.06
AD-Familial	ADSP_OldLabels_10K_UKBAC1_controls_cleaned	0.66	1.71	1.66	1.01	5.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	AD-Familial	0.00	-0.30	0.45	0.34	3.34
AD-Familial	ADSP_OldLabels_10K_UKBAC1_controls_cleaned	0.01	0.92	1.53	1.28	2.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	105	105	
AD-Familial	14	14