Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	AD-GWAS	2.62e-01	1.90e-02	1.19e-03	6.67e-05
AD-GWAS	ADSP_OldLabels_10K_UKBAC1_controls_cleaned	2.32e-01	1.15e-01	3.37e-03	1.70e-06



Evaluating how well ADSP_OldLabels_10K_UKBAC1_controls_cleaned genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	AD-GWAS	0.72	0.53	2.16	1.39	3.89
AD-GWAS	ADSP_OldLabels_10K_UKBAC1_controls_cleaned	0.65	0.80	1.95	1.31	5.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	AD-GWAS	0.00	-0.06	0.20	1.18	0.25
AD-GWAS	ADSP_OldLabels_10K_UKBAC1_controls_cleaned	0.01	1.28	2.10	2.23	5.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_10K_UKBAC1_controls_cleaned	105	105	
AD-GWAS	25	24	HLA -DRB1