Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	AD-Familial	2.04e-04	5.88e-09	1.48e-08	2.45e-09
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar	7.39e-06	5.54e-04	1.96e-07	1.77e-06
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	AD-Familial Exclusive	5.00e-04	4.28e-07	9.24e-08	4.90e-08
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	2.84e-05	2.22e-03	1.22e-07	4.18e-06
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	Overlap	3.07e-02	2.21e-02	1.35e-02	2.55e-02
AD-Familial Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	9.76e-06	9.10e-04	3.38e-19	3.20e-06



Evaluating how well ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	AD-Familial	0.93	2.58	5.51	3.03	5.23
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar	0.70	3.00	4.66	1.46	6.60
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	AD-Familial Exclusive	0.92	2.62	5.66	2.96	5.36
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	0.69	3.43	3.75	1.53	6.60
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	Overlap	0.93	1.05	2.05	1.42	2.07
AD-Familial Exclusive	Overlap	1.00	5.01	2.17	2.70	2.62
Overlap	Exclusives	0.68	2.32	3.22	0.87	6.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	AD-Familial	0.00	0.48	8.86	4.63	10.67
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar	0.02	4.02	18.49	2.39	24.43
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	AD-Familial Exclusive	0.00	0.51	7.63	3.55	2.31
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	0.01	7.90	7.03	3.75	7.76
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	Overlap	0.00	0.21	2.82	0.89	0.60
AD-Familial Exclusive	Overlap	0.20	738.77	598.61	264.95	969.04
Overlap	Exclusives	0.02	19.62	25.69	6.23	30.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC1_cases_uniqueVar Exclusive	91	91	
AD-Familial Exclusive	12	12	
Overlap	2	2