Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	AD-Familial	9.05e-01	1.26e-01	2.12e-02	3.33e-04
AD-Familial	ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	2.00e-01	7.50e-02	1.33e-05	7.23e-08



Evaluating how well ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	AD-Familial	0.79	0.59	2.71	1.38	3.85
AD-Familial	ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	0.66	2.31	1.68	1.02	4.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	AD-Familial	0.00	-0.50	2.69	0.58	0.50
AD-Familial	ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	0.01	2.62	1.04	1.40	1.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC1_controls_uniqueVar	81	81	
AD-Familial	14	14