Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-Familial	3.28e-06	9.72e-08	1.47e-07	1.00e-07
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar	1.88e-05	7.94e-03	4.86e-32	7.07e-16
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-Familial Exclusive	1.56e-03	3.48e-05	2.50e-04	5.34e-05
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	5.51e-05	1.03e-02	2.56e-30	6.23e-16
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	Overlap	2.45e-04	1.46e-03	1.95e-04	5.50e-04
AD-Familial Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.69e-04
Overlap	Exclusives	1.87e-10	4.08e-05	9.34e-36	6.78e-18



Evaluating how well ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-Familial	0.89	3.07	4.26	2.35	5.80
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar	0.65	2.28	4.94	0.98	8.42
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-Familial Exclusive	0.88	3.01	3.95	2.28	5.06
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	0.65	2.18	5.14	0.81	7.41
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	Overlap	0.94	2.93	2.98	2.42	3.39
AD-Familial Exclusive	Overlap	1.00	8.02	3.61	3.46	3.69
Overlap	Exclusives	0.68	1.95	6.96	1.09	9.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-Familial	0.00	0.03	3.32	1.36	5.03
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar	0.03	7.44	20.79	3.55	18.12
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-Familial Exclusive	0.00	-0.40	2.43	0.39	3.64
AD-Familial Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	0.02	2.56	8.56	1.58	9.32
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	Overlap	0.00	2.20	1.55	1.94	4.48
AD-Familial Exclusive	Overlap	0.34	1563.94	1953.50	861.44	241.36
Overlap	Exclusives	0.04	5.46	25.25	2.95	24.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	255	255	
AD-Familial Exclusive	10	10	
Overlap	4	4