Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-GWAS	2.39e-01	3.67e-03	7.04e-03	1.62e-05
AD-GWAS Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar	5.67e-02	3.33e-05	2.99e-14	4.19e-20
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-GWAS Exclusive	4.23e-01	9.68e-03	1.08e-02	5.42e-05
AD-GWAS Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	5.23e-02	5.46e-05	1.21e-13	1.07e-19
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.75e-01
AD-GWAS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.50e-04	2.10e-06	4.67e-05	8.47e-16



Evaluating how well ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-GWAS	0.74	1.87	3.18	1.75	3.75
AD-GWAS Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar	0.65	1.85	4.96	1.57	8.59
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-GWAS Exclusive	0.74	1.71	2.84	1.64	3.95
AD-GWAS Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	0.65	2.17	4.23	1.33	7.81
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	Overlap	0.91	1.90	1.48	1.78	1.39
AD-GWAS Exclusive	Overlap	1.00	1.80	1.74	1.98	1.59
Overlap	Exclusives	0.67	1.03	5.86	0.83	9.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-GWAS	0.00	0.74	2.71	0.89	2.46
AD-GWAS Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar	0.02	1.55	4.45	1.47	5.56
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	AD-GWAS Exclusive	0.00	0.43	1.69	0.49	3.01
AD-GWAS Exclusive	ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	0.02	1.63	3.24	0.99	4.94
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	Overlap	0.00	3.02	4.50	2.57	-0.11
AD-GWAS Exclusive	Overlap	0.06	79.49	285.60	476.67	78.41
Overlap	Exclusives	0.03	2.82	13.27	1.15	17.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC5_cases_uniqueVar Exclusive	258	258	
AD-GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1