Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	AD-Familial	3.53e-01	8.05e-01	5.95e-01	2.35e-02
AD-Familial	ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	3.49e-05	7.67e-01	2.03e-11	8.73e-12



Evaluating how well ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	AD-Familial	0.68	-0.42	0.04	-0.13	2.51
AD-Familial	ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	0.60	0.51	-0.56	-0.11	5.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	AD-Familial	0.00	-1.19	-0.85	-0.97	0.23
AD-Familial	ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	0.02	-0.12	-1.06	-0.23	2.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	316	316	
AD-Familial	14	14