Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	AD-GWAS	7.25e-02	5.84e-01	3.86e-01	3.67e-03
AD-GWAS	ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	3.21e-07	2.67e-01	6.87e-02	1.05e-09



Evaluating how well ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	AD-GWAS	0.66	-0.26	0.96	0.23	3.20
AD-GWAS	ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	0.59	-0.36	-0.99	-0.25	5.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	AD-GWAS	0.00	-1.11	0.28	-0.40	0.84
AD-GWAS	ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	0.02	0.11	-0.24	0.17	4.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_OldLabels_5K_UKBAC5_controls_uniqueVar	316	316	
AD-GWAS	25	24	HLA -DRB1