Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB200K_444priorityGenes Exclusive	BRCA-gwas-unique	3.23e-02	4.58e-01	3.32e-09	1.67e-05
BRCA-gwas-unique Exclusive	UKB200K_444priorityGenes	3.99e-02	3.77e-01	1.42e-16	1.32e-16
UKB200K_444priorityGenes Exclusive	BRCA-gwas-unique Exclusive	1.29e-02	5.42e-01	3.45e-08	8.43e-04
BRCA-gwas-unique Exclusive	UKB200K_444priorityGenes Exclusive	2.98e-02	5.99e-01	2.11e-16	1.26e-14
UKB200K_444priorityGenes Exclusive	Overlap	5.34e-01	1.56e-01	8.94e-03	2.50e-04
BRCA-gwas-unique Exclusive	Overlap	1.42e-01	5.96e-02	8.92e-04	2.59e-04
Overlap	Exclusives	2.30e-10	1.77e-09	6.27e-71	1.39e-30



Evaluating how well UKB200K_444priorityGenes genes are linked to BRCA-gwas-unique genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB200K_444priorityGenes Exclusive	BRCA-gwas-unique	0.61	-0.46	0.71	1.23	5.45
BRCA-gwas-unique Exclusive	UKB200K_444priorityGenes	0.64	-0.26	0.89	1.16	10.26
UKB200K_444priorityGenes Exclusive	BRCA-gwas-unique Exclusive	0.60	-1.19	0.36	0.85	4.04
BRCA-gwas-unique Exclusive	UKB200K_444priorityGenes Exclusive	0.63	-0.31	0.63	1.19	9.39
UKB200K_444priorityGenes Exclusive	Overlap	0.88	2.02	2.32	2.04	3.54
BRCA-gwas-unique Exclusive	Overlap	0.92	2.37	2.70	3.17	3.78
Overlap	Exclusives	0.67	2.34	6.87	2.39	14.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB200K_444priorityGenes Exclusive	BRCA-gwas-unique	0.02	-2.45	2.02	1.28	9.76
BRCA-gwas-unique Exclusive	UKB200K_444priorityGenes	0.04	0.54	4.36	3.11	19.99
UKB200K_444priorityGenes Exclusive	BRCA-gwas-unique Exclusive	0.01	-3.83	0.18	-0.02	3.78
BRCA-gwas-unique Exclusive	UKB200K_444priorityGenes Exclusive	0.04	0.44	3.97	3.72	17.49
UKB200K_444priorityGenes Exclusive	Overlap	0.03	27.21	57.62	34.63	32.46
BRCA-gwas-unique Exclusive	Overlap	0.00	1.47	2.20	4.63	9.07
Overlap	Exclusives	0.06	4.11	12.49	5.14	23.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB200K_444priorityGenes Exclusive	433	431	;PRAMEF11
BRCA-gwas-unique Exclusive	157	157	
Overlap	7	7