Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-familial	9.94e-01	7.27e-01	8.49e-01	3.28e-08
BRCA-familial Exclusive	UKB200K_1059_nonPriorityGenes	2.84e-36	8.63e-02	4.52e-47	3.96e-04
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-familial Exclusive	9.93e-01	8.54e-01	9.24e-01	9.47e-08
BRCA-familial Exclusive	UKB200K_1059_nonPriorityGenes Exclusive	1.42e-36	1.24e-01	1.75e-49	4.25e-04
UKB200K_1059_nonPriorityGenes Exclusive	Overlap	1.05e-01	9.92e-02	9.92e-02	1.66e-01
BRCA-familial Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.60e-03	1.65e-01	1.27e-53	9.37e-03



Evaluating how well UKB200K_1059_nonPriorityGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-familial	0.85	0.26	1.46	0.39	6.38
BRCA-familial Exclusive	UKB200K_1059_nonPriorityGenes	0.52	0.12	-1.42	-0.31	1.71
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-familial Exclusive	0.85	0.16	1.01	0.17	5.80
BRCA-familial Exclusive	UKB200K_1059_nonPriorityGenes Exclusive	0.52	0.17	-1.05	-0.30	1.71
UKB200K_1059_nonPriorityGenes Exclusive	Overlap	0.94	1.20	1.99	1.22	1.31
BRCA-familial Exclusive	Overlap	1.00	1.41	1.49	1.94	1.59
Overlap	Exclusives	0.52	0.54	-1.21	-0.46	2.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-familial	0.01	-1.90	-4.29	-0.78	1.82
BRCA-familial Exclusive	UKB200K_1059_nonPriorityGenes	0.06	0.52	-0.48	0.00	1.12
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-familial Exclusive	0.01	-1.65	-4.23	-0.80	19.47
BRCA-familial Exclusive	UKB200K_1059_nonPriorityGenes Exclusive	0.06	0.35	-0.46	-0.13	0.89
UKB200K_1059_nonPriorityGenes Exclusive	Overlap	0.00	1.44	5.09	1.83	0.38
BRCA-familial Exclusive	Overlap	0.03	102.79	73.89	133.63	96.18
Overlap	Exclusives	0.06	4.36	4.48	0.60	5.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB200K_1059_nonPriorityGenes Exclusive	1054	1042	;AL669918.1;CHD2;ZNF709;BECN2;CROCC2;TEX52;AC093525.2;OPN1MW;CCDC7;ZNF816-ZNF321P;SSPO
BRCA-familial Exclusive	22	22	
Overlap	1	1