Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-somatic	8.87e-02	7.48e-01	3.29e-01	2.39e-10
BRCA-somatic Exclusive	UKB200K_1059_nonPriorityGenes	1.95e-20	8.33e-03	2.57e-46	1.34e-02
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-somatic Exclusive	5.99e-02	7.65e-01	2.63e-01	4.19e-09
BRCA-somatic Exclusive	UKB200K_1059_nonPriorityGenes Exclusive	5.46e-20	9.22e-03	4.56e-42	1.20e-02
UKB200K_1059_nonPriorityGenes Exclusive	Overlap	8.50e-01	5.22e-01	8.32e-01	7.46e-03
BRCA-somatic Exclusive	Overlap	1.38e-03	8.83e-03	1.38e-03	1.60e-03
Overlap	Exclusives	2.57e-02	1.67e-01	4.88e-226	4.67e-04



Evaluating how well UKB200K_1059_nonPriorityGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-somatic	0.84	-5.20	0.36	-3.44	7.79
BRCA-somatic Exclusive	UKB200K_1059_nonPriorityGenes	0.50	-1.16	-3.19	-0.94	0.10
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-somatic Exclusive	0.83	-5.44	0.31	-3.18	7.58
BRCA-somatic Exclusive	UKB200K_1059_nonPriorityGenes Exclusive	0.50	-1.02	-3.08	-1.15	-0.02
UKB200K_1059_nonPriorityGenes Exclusive	Overlap	0.95	-0.43	0.92	-0.07	2.63
BRCA-somatic Exclusive	Overlap	0.99	2.48	2.81	2.59	2.84
Overlap	Exclusives	0.53	1.24	0.35	0.16	4.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-somatic	0.03	-2.86	-0.87	-1.02	67.11
BRCA-somatic Exclusive	UKB200K_1059_nonPriorityGenes	0.05	-0.24	-2.07	-0.43	-0.18
UKB200K_1059_nonPriorityGenes Exclusive	BRCA-somatic Exclusive	0.02	-2.98	0.27	-0.96	57.97
BRCA-somatic Exclusive	UKB200K_1059_nonPriorityGenes Exclusive	0.05	-0.11	-2.43	-0.82	-0.54
UKB200K_1059_nonPriorityGenes Exclusive	Overlap	0.00	-0.98	0.08	-0.77	11.97
BRCA-somatic Exclusive	Overlap	0.01	0.49	26.01	54.18	13.39
Overlap	Exclusives	0.07	3.22	3.31	1.14	5.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB200K_1059_nonPriorityGenes Exclusive	1051	1039	;ZNF709;AC093525.2;SSPO;CROCC2;AL669918.1;OPN1MW;TEX52;CHD2;ZNF816-ZNF321P;CCDC7;BECN2
BRCA-somatic Exclusive	34	34	
Overlap	3	3