Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_new_clean Exclusive	2020_5k	5.13e-02	3.01e-01	3.36e-01	2.28e-01
2020_5k Exclusive	2020_new_clean	7.28e-01	9.82e-01	5.03e-01	7.13e-01
2020_new_clean Exclusive	2020_5k Exclusive	1.19e-02	9.55e-02	1.27e-01	1.84e-01
2020_5k Exclusive	2020_new_clean Exclusive	5.37e-01	9.34e-01	4.53e-01	3.41e-01
2020_new_clean Exclusive	Overlap	5.40e-01	5.59e-01	4.34e-01	5.88e-01
2020_5k Exclusive	Overlap	9.78e-01	8.78e-01	9.79e-01	8.63e-01
Overlap	Exclusives	9.14e-01	2.32e-01	2.03e-01	9.12e-01



Evaluating how well 2020_new_clean genes are linked to 2020_5k genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_new_clean Exclusive	2020_5k	0.52	1.44	0.76	1.02	1.00
2020_5k Exclusive	2020_new_clean	0.49	0.10	0.24	0.22	-0.21
2020_new_clean Exclusive	2020_5k Exclusive	0.53	1.83	1.45	1.37	0.92
2020_5k Exclusive	2020_new_clean Exclusive	0.48	-0.11	0.12	0.29	-0.47
2020_new_clean Exclusive	Overlap	0.48	-0.61	-0.71	-0.55	-0.38
2020_5k Exclusive	Overlap	0.54	0.03	0.34	0.27	0.32
Overlap	Exclusives	0.50	0.24	1.20	1.22	0.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_new_clean Exclusive	2020_5k	0.01	0.47	0.78	0.01	0.37
2020_5k Exclusive	2020_new_clean	0.01	1.50	1.08	1.86	1.00
2020_new_clean Exclusive	2020_5k Exclusive	0.01	0.37	1.19	0.44	0.63
2020_5k Exclusive	2020_new_clean Exclusive	0.01	1.15	1.77	2.16	0.23
2020_new_clean Exclusive	Overlap	0.00	-0.42	-0.82	-0.65	-0.27
2020_5k Exclusive	Overlap	0.00	0.11	-0.18	0.32	0.21
Overlap	Exclusives	0.01	-0.39	0.18	0.12	-0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_new_clean Exclusive	88	88	
2020_5k Exclusive	91	89	AL162417.1;RFPL2
Overlap	15	13	TNFSF12-TNFSF13;PRAMEF11