Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2020_10k Exclusive	2020_10k_clean	1.90e-01	2.82e-01	6.53e-01	2.12e-01
2020_10k_clean Exclusive	2020_10k	4.71e-01	4.61e-01	5.17e-01	2.20e-01
2020_10k Exclusive	2020_10k_clean Exclusive	5.56e-02	6.89e-02	7.52e-02	1.17e-01
2020_10k_clean Exclusive	2020_10k Exclusive	1.94e-01	9.44e-02	1.96e-01	1.28e-01
2020_10k Exclusive	Overlap	8.33e-01	7.52e-01	5.33e-01	8.20e-01
2020_10k_clean Exclusive	Overlap	6.18e-01	7.18e-01	6.37e-01	8.03e-01
Overlap	Exclusives	1.51e-01	6.75e-01	4.50e-01	3.12e-01



Evaluating how well 2020_10k genes are linked to 2020_10k_clean genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_10k Exclusive	2020_10k_clean	0.53	1.56	1.03	0.89	1.17
2020_10k_clean Exclusive	2020_10k	0.53	0.45	0.90	0.82	1.01
2020_10k Exclusive	2020_10k_clean Exclusive	0.56	2.13	1.64	1.78	1.67
2020_10k_clean Exclusive	2020_10k Exclusive	0.55	1.30	1.78	1.76	1.21
2020_10k Exclusive	Overlap	0.50	-0.62	-0.80	-0.71	-0.15
2020_10k_clean Exclusive	Overlap	0.51	-0.73	-0.39	-0.29	0.28
Overlap	Exclusives	0.48	-0.99	-0.38	-0.74	-0.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2020_10k Exclusive	2020_10k_clean	0.01	0.74	-0.03	0.29	0.11
2020_10k_clean Exclusive	2020_10k	0.00	-0.15	-0.17	0.10	0.15
2020_10k Exclusive	2020_10k_clean Exclusive	0.00	0.47	0.40	0.74	0.53
2020_10k_clean Exclusive	2020_10k Exclusive	0.00	0.30	0.49	0.41	0.52
2020_10k Exclusive	Overlap	0.00	-0.48	-0.56	-0.61	-0.24
2020_10k_clean Exclusive	Overlap	0.00	-0.93	-0.63	-0.64	-0.42
Overlap	Exclusives	0.00	-0.95	-0.59	-1.08	-0.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2020_10k Exclusive	42	42	
2020_10k_clean Exclusive	64	60	RFPL2;PRAMEF11;AL162417.1;TNFSF12-TNFSF13
Overlap	48	48