Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dbgap_5k Exclusive	2020_5k	3.44e-02	7.65e-02	1.70e-01	4.89e-02
2020_5k Exclusive	dbgap_5k	6.88e-01	6.50e-01	8.64e-01	6.14e-01
dbgap_5k Exclusive	2020_5k Exclusive	5.24e-02	8.23e-02	1.75e-01	6.54e-02
2020_5k Exclusive	dbgap_5k Exclusive	6.64e-01	6.20e-01	7.82e-01	6.74e-01
dbgap_5k Exclusive	Overlap	6.50e-01	7.76e-01	8.48e-01	4.02e-01
2020_5k Exclusive	Overlap	5.42e-01	6.05e-01	2.74e-01	8.77e-01
Overlap	Exclusives	3.52e-01	6.03e-01	4.83e-12	3.82e-01



Evaluating how well dbgap_5k genes are linked to 2020_5k genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dbgap_5k Exclusive	2020_5k	0.56	2.35	2.61	2.56	2.15
2020_5k Exclusive	dbgap_5k	0.52	0.64	1.03	1.13	0.38
dbgap_5k Exclusive	2020_5k Exclusive	0.56	2.31	2.44	2.66	2.06
2020_5k Exclusive	dbgap_5k Exclusive	0.52	1.03	1.25	1.68	0.45
dbgap_5k Exclusive	Overlap	0.64	0.48	0.03	0.09	0.83
2020_5k Exclusive	Overlap	0.53	-0.56	-0.88	-0.96	0.28
Overlap	Exclusives	0.48	-2.80	0.83	0.21	-1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dbgap_5k Exclusive	2020_5k	0.01	0.75	1.31	1.08	0.68
2020_5k Exclusive	dbgap_5k	0.01	1.86	1.38	1.03	1.39
dbgap_5k Exclusive	2020_5k Exclusive	0.01	1.11	1.21	1.07	1.77
2020_5k Exclusive	dbgap_5k Exclusive	0.01	0.68	1.51	2.36	1.36
dbgap_5k Exclusive	Overlap	0.00	-0.25	-1.06	-0.43	-0.06
2020_5k Exclusive	Overlap	0.00	3.96	0.40	0.80	1.37
Overlap	Exclusives	0.01	-0.88	0.72	0.01	-0.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dbgap_5k Exclusive	94	94	
2020_5k Exclusive	102	98	AL162417.1;PRAMEF11;RFPL2;TNFSF12-TNFSF13
Overlap	4	4