Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dbGaP_5k Exclusive	final25	2.93e-03	9.61e-04	6.37e-02	1.20e-05
final25 Exclusive	dbGaP_5k	3.76e-01	6.35e-01	3.70e-01	4.39e-01
dbGaP_5k Exclusive	final25 Exclusive	3.03e-03	4.82e-04	2.55e-02	4.72e-05
final25 Exclusive	dbGaP_5k Exclusive	4.31e-01	6.30e-01	1.46e-01	4.40e-01
dbGaP_5k Exclusive	Overlap	6.11e-01	9.92e-02	4.91e-01	1.57e-01
final25 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.16e-03	9.40e-03	1.97e-32	2.16e-02



Evaluating how well dbGaP_5k genes are linked to final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dbGaP_5k Exclusive	final25	0.74	1.93	3.79	1.66	4.58
final25 Exclusive	dbGaP_5k	0.50	1.55	0.74	0.43	-0.23
dbGaP_5k Exclusive	final25 Exclusive	0.73	2.13	3.66	2.04	3.72
final25 Exclusive	dbGaP_5k Exclusive	0.49	1.37	0.76	0.59	-0.30
dbGaP_5k Exclusive	Overlap	0.89	0.38	-367148904465568.50	-0.20	1.46
final25 Exclusive	Overlap	1.00	1.31	111424462830387.00	1.61	1.63
Overlap	Exclusives	0.58	inf	3.91	2.23	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dbGaP_5k Exclusive	final25	0.00	1.07	4.13	0.69	0.15
final25 Exclusive	dbGaP_5k	0.01	1.52	1.33	0.78	0.86
dbGaP_5k Exclusive	final25 Exclusive	0.00	1.75	4.62	1.52	2.60
final25 Exclusive	dbGaP_5k Exclusive	0.01	2.35	0.26	1.75	0.28
dbGaP_5k Exclusive	Overlap	0.00	-0.23	-inf	-0.51	0.14
final25 Exclusive	Overlap	0.02	28.68	32920936630948200.00	58.72	38.18
Overlap	Exclusives	0.01	inf	10.23	6.19	8.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dbGaP_5k Exclusive	97	97	
final25 Exclusive	24	23	HLA -DRB1
Overlap	1	1