Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
scz eaml	gwas	7.39e-01	1.65e-01	1.02e-01	6.83e-03
gwas	scz eaml	8.39e-01	8.71e-01	3.59e-02	2.03e-01



Evaluating how well scz eaml genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
scz eaml	gwas	0.61	0.81	1.72	0.34	3.96
gwas	scz eaml	0.47	0.77	0.03	0.18	-1.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
scz eaml	gwas	0.01	0.48	0.17	-0.01	2.72
gwas	scz eaml	0.01	0.71	0.91	0.26	-0.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
scz eaml	188	187	UBE2NL
gwas	104	79	RN7SKP19;DDX10P2;LINC01415;KRT18P50;LINC02404;LINC01648;LINC01645;GULOP;RFPL4AP3;LINC01470;LINC02033;C3orf49;RNU6-1029P;LINC01360;RPSAP2;NOP56P1;MIR29B2CHG;CAPZA1P4;LINC02057;HSPD1P6;AS1;PTGES3P4;PAK6;SINHCAFP3;ACTG1P22