Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
237 Exclusive	GS1	9.39e-01	3.70e-01	6.11e-01	6.26e-03
GS1 Exclusive	237	4.17e-01	8.13e-01	1.53e-01	8.59e-01
237 Exclusive	GS1 Exclusive	8.46e-01	4.37e-01	7.46e-01	3.91e-03
GS1 Exclusive	237 Exclusive	4.77e-01	9.10e-01	1.20e-01	8.69e-01
237 Exclusive	Overlap	1.41e-01	2.40e-01	4.72e-01	1.66e-01
GS1 Exclusive	Overlap	6.11e-01	1.12e-01	6.11e-01	1.33e-01
Overlap	Exclusives	2.32e-10	4.72e-01	7.57e-46	9.85e-01



Evaluating how well 237 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
237 Exclusive	GS1	0.60	-0.13	0.62	-0.00	2.77
GS1 Exclusive	237	0.51	0.23	0.14	0.15	0.44
237 Exclusive	GS1 Exclusive	0.61	-0.01	0.57	-0.11	2.63
GS1 Exclusive	237 Exclusive	0.51	0.44	0.06	0.28	0.45
237 Exclusive	Overlap	0.07	-0.53	-0.94	-0.67	-1.39
GS1 Exclusive	Overlap	0.07	-0.32	-0.86	-0.81	-1.57
Overlap	Exclusives	0.50	-1.24	-1.31	-1.06	-0.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
237 Exclusive	GS1	0.00	-0.16	0.62	-0.03	1.85
GS1 Exclusive	237	0.01	-0.32	-0.37	-0.37	-0.10
237 Exclusive	GS1 Exclusive	0.00	-0.10	0.67	-0.13	0.26
GS1 Exclusive	237 Exclusive	0.01	-0.26	-0.45	-0.27	-0.06
237 Exclusive	Overlap	0.00	-0.32	-0.48	-0.15	-0.30
GS1 Exclusive	Overlap	0.00	-0.29	-0.42	-0.13	-0.66
Overlap	Exclusives	0.02	-0.98	-0.70	-0.98	-0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
237 Exclusive	236	235	CORO7-PAM16
GS1 Exclusive	63	62	PAK6
Overlap	1	1