Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
237genes Exclusive	GS2	7.07e-01	5.36e-01	8.73e-01	6.51e-01
GS2 Exclusive	237genes	5.16e-01	8.01e-01	9.15e-03	7.83e-01
237genes Exclusive	GS2 Exclusive	5.93e-01	3.82e-01	7.27e-01	6.16e-01
GS2 Exclusive	237genes Exclusive	4.22e-01	8.27e-01	1.30e-02	7.85e-01
237genes Exclusive	Overlap	2.06e-01	3.35e-01	1.33e-01	6.31e-01
GS2 Exclusive	Overlap	1.12e-01	1.33e-01	1.25e-01	1.49e-01
Overlap	Exclusives	1.57e-01	6.05e-01	3.48e-17	3.52e-01



Evaluating how well 237genes genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
237genes Exclusive	GS2	0.53	-1.00	-1.22	-0.76	0.61
GS2 Exclusive	237genes	0.49	-0.91	-1.18	-0.69	-0.23
237genes Exclusive	GS2 Exclusive	0.53	-1.15	-1.49	-0.98	0.50
GS2 Exclusive	237genes Exclusive	0.49	-1.09	-1.05	-0.96	-0.60
237genes Exclusive	Overlap	0.63	1.36	0.94	2.03	0.36
GS2 Exclusive	Overlap	0.92	2.53	2.30	1.86	1.49
Overlap	Exclusives	0.51	0.36	-0.05	0.27	0.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
237genes Exclusive	GS2	0.00	-1.52	-1.56	-1.57	-0.17
GS2 Exclusive	237genes	0.01	-0.96	-1.46	-1.08	-0.74
237genes Exclusive	GS2 Exclusive	0.00	-1.59	-0.36	-0.93	-0.20
GS2 Exclusive	237genes Exclusive	0.01	-1.30	-1.49	-1.20	-1.08
237genes Exclusive	Overlap	0.00	0.46	-0.15	-0.06	-0.19
GS2 Exclusive	Overlap	0.00	5.55	1.29	0.18	1.15
Overlap	Exclusives	0.02	1.03	1.55	1.26	1.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
237genes Exclusive	236	235	CORO7-PAM16
GS2 Exclusive	45	44	RP11-73M18.2
Overlap	1	1