Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
154AD Exclusive	25GS	5.98e-01	6.39e-01	7.11e-01	6.89e-02
25GS Exclusive	154AD	7.63e-01	7.24e-01	1.06e-02	6.66e-01
154AD Exclusive	25GS Exclusive	5.70e-01	5.32e-01	4.74e-01	1.48e-01
25GS Exclusive	154AD Exclusive	7.16e-01	8.54e-01	6.23e-03	7.13e-01
154AD Exclusive	Overlap	7.54e-01	4.28e-01	9.19e-01	4.17e-01
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.28e-02
Overlap	Exclusives	4.76e-02	1.40e-02	1.56e-13	2.39e-02



Evaluating how well 154AD genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
154AD Exclusive	25GS	0.60	-0.27	0.47	-0.33	1.76
25GS Exclusive	154AD	0.51	1.46	1.05	0.95	0.44
154AD Exclusive	25GS Exclusive	0.59	-0.26	0.30	-0.39	1.24
25GS Exclusive	154AD Exclusive	0.50	1.30	0.76	0.73	0.31
154AD Exclusive	Overlap	0.76	-0.04	-0.04	0.13	1.38
25GS Exclusive	Overlap	1.00	2.43	1.70	2.13	2.54
Overlap	Exclusives	0.55	0.75	3.01	1.63	2.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
154AD Exclusive	25GS	0.00	-0.23	0.77	-0.28	0.96
25GS Exclusive	154AD	0.01	2.23	0.47	1.21	0.35
154AD Exclusive	25GS Exclusive	0.00	-0.23	0.83	-0.21	0.27
25GS Exclusive	154AD Exclusive	0.01	0.25	-0.11	-0.16	-0.34
154AD Exclusive	Overlap	0.00	-0.03	-0.82	-0.20	0.57
25GS Exclusive	Overlap	0.05	134.73	144.40	105.29	4.49
Overlap	Exclusives	0.02	15.73	7.39	8.82	12.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
154AD Exclusive	152	151	AC018755.2
25GS Exclusive	23	23	
Overlap	2	2