Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gemb Exclusive	gwas 1	6.34e-02	1.64e-02	3.83e-05	1.13e-01
gwas 1 Exclusive	gemb	1.19e-03	4.92e-02	9.80e-02	8.00e-05
gemb Exclusive	gwas 1 Exclusive	6.38e-02	1.08e-02	3.56e-04	3.32e-01
gwas 1 Exclusive	gemb Exclusive	1.14e-03	6.90e-02	6.62e-02	1.83e-04
gemb Exclusive	Overlap	5.53e-01	5.40e-01	2.32e-02	1.73e-02
gwas 1 Exclusive	Overlap	2.26e-01	6.87e-01	3.22e-02	2.00e-02
Overlap	Exclusives	2.21e-03	8.38e-02	2.36e-51	7.63e-15



Evaluating how well gemb genes are linked to gwas 1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gemb Exclusive	gwas 1	0.55	-2.76	-3.87	-1.33	1.57
gwas 1 Exclusive	gemb	0.62	-3.95	-2.38	-1.55	4.44
gemb Exclusive	gwas 1 Exclusive	0.54	-2.20	-4.47	-1.68	0.98
gwas 1 Exclusive	gemb Exclusive	0.61	-3.98	-2.58	-1.53	4.33
gemb Exclusive	Overlap	0.96	1.44	1.47	1.62	2.20
gwas 1 Exclusive	Overlap	0.96	1.65	1.28	1.73	2.56
Overlap	Exclusives	0.69	0.88	2.50	1.74	9.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gemb Exclusive	gwas 1	0.01	-0.76	-0.53	0.40	2.43
gwas 1 Exclusive	gemb	0.01	-2.13	-1.53	-0.88	4.11
gemb Exclusive	gwas 1 Exclusive	0.00	-1.78	-2.43	-1.09	0.02
gwas 1 Exclusive	gemb Exclusive	0.01	-2.62	-1.83	-0.96	1.70
gemb Exclusive	Overlap	0.03	1.74	147.19	31.23	184.89
gwas 1 Exclusive	Overlap	0.00	-0.20	0.49	0.95	0.24
Overlap	Exclusives	0.02	3.28	3.72	2.70	7.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gemb Exclusive	130	130	
gwas 1 Exclusive	102	77	DDX10P2;RPSAP2;RNU6-1029P;GULOP;LINC02404;AS1;PAK6;CAPZA1P4;LINC01648;PTGES3P4;ACTG1P22;NOP56P1;LINC01645;RN7SKP19;LINC01415;LINC01360;C3orf49;LINC01470;HSPD1P6;LINC02057;LINC02033;MIR29B2CHG;RFPL4AP3;SINHCAFP3;KRT18P50
Overlap	2	2