Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gemb	gwas2	8.55e-03	2.10e-02	2.48e-05	2.52e-01
gwas2	gemb	7.41e-03	5.16e-01	3.66e-02	1.66e-07



Evaluating how well gemb genes are linked to gwas2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gemb	gwas2	0.54	-3.02	-3.61	-1.02	1.61
gwas2	gemb	0.65	-3.43	-1.48	-0.60	5.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gemb	gwas2	0.01	-0.99	-2.74	-0.42	0.54
gwas2	gemb	0.01	-2.57	-1.84	-0.75	2.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gemb	132	132	
gwas2	120	104	RP11-490G2.2;RP11-399D6.2;CTD-2008L17.2;ALMS1P;RP11-507B12.2;RP11-53O19.3;RP11-10L12.4;RP11-73M18.2;LINC01068;AC068490.2;LINC01088;RP11-586K2.1;RP11-165J3.6;ENSG00000262319;LINC00320;PAK6