Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10K clean 2 Exclusive	14GS	9.53e-01	9.64e-01	8.50e-01	3.39e-01
14GS Exclusive	10K clean 2	6.61e-01	1.46e-02	1.89e-03	3.70e-03
10K clean 2 Exclusive	14GS Exclusive	9.61e-01	9.97e-01	9.95e-01	7.48e-01
14GS Exclusive	10K clean 2 Exclusive	6.20e-01	1.95e-02	5.26e-04	4.55e-03
10K clean 2 Exclusive	Overlap	2.50e-01	5.40e-01	2.34e-01	3.69e-02
14GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.61e-02	2.26e-03	2.48e-30	1.27e-03



Evaluating how well 10K clean 2 genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10K clean 2 Exclusive	14GS	0.60	-0.29	0.14	-0.02	1.84
14GS Exclusive	10K clean 2	0.57	2.18	2.19	2.04	2.43
10K clean 2 Exclusive	14GS Exclusive	0.58	-0.37	-0.06	-0.24	0.84
14GS Exclusive	10K clean 2 Exclusive	0.56	2.16	1.92	1.94	2.48
10K clean 2 Exclusive	Overlap	0.92	1.35	1.28	1.26	1.99
14GS Exclusive	Overlap	1.00	2.40	2.47	2.77	2.84
Overlap	Exclusives	0.62	2.78	5.06	2.70	4.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10K clean 2 Exclusive	14GS	0.00	-0.18	0.16	0.01	0.31
14GS Exclusive	10K clean 2	0.01	2.01	0.32	1.58	1.19
10K clean 2 Exclusive	14GS Exclusive	0.00	-0.33	-0.07	-0.24	-0.05
14GS Exclusive	10K clean 2 Exclusive	0.01	0.54	-0.03	0.39	0.53
10K clean 2 Exclusive	Overlap	0.00	0.04	0.10	0.69	0.08
14GS Exclusive	Overlap	0.04	62.66	204.12	173.96	92.25
Overlap	Exclusives	0.04	56.24	64.83	47.91	55.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10K clean 2 Exclusive	105	101	;AC131097.2;RFPL2;TNFSF12-TNFSF13
14GS Exclusive	23	22	HLA -DRB1
Overlap	2	2