Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GroupA	GroupB	8.33e-01	6.41e-01	8.84e-01	2.30e-02
GroupB	GroupA	9.62e-01	8.26e-01	9.90e-02	9.71e-01



Evaluating how well GroupA genes are linked to GroupB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.83	0.25	0.83	0.19	2.32
GroupB	GroupA	0.50	0.09	-0.37	-0.36	0.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.00	0.16	0.45	-0.07	1.14
GroupB	GroupA	0.00	0.33	-0.28	-0.27	0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GroupA	5	5	
GroupB	4	4