Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_10K_clean3	14GS	1.87e-03	3.11e-04	1.14e-02	1.77e-04
14GS	EAML_10K_clean3	4.69e-02	8.86e-03	4.13e-07	8.26e-03



Evaluating how well EAML_10K_clean3 genes are linked to 14GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean3	14GS	0.83	2.25	4.88	1.89	4.33
14GS	EAML_10K_clean3	0.60	5.61	4.10	3.59	3.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean3	14GS	0.00	5.29	9.84	4.04	3.07
14GS	EAML_10K_clean3	0.01	6.63	4.65	4.18	3.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_10K_clean3	80	75	;TNFSF12-TNFSF13;AL162417.1;PRAMEF11;RFPL2
14GS	14	14