Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_cases	AD-Familial	1.17e-01	1.28e-01	8.87e-03	5.02e-04
AD-Familial	ADSP_10K_UKBaltfilt_cohortAC1_cases	1.58e-02	6.08e-03	1.61e-23	8.88e-18



Evaluating how well ADSP_10K_UKBaltfilt_cohortAC1_cases genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_cases	AD-Familial	0.81	2.45	2.57	1.87	3.58
AD-Familial	ADSP_10K_UKBaltfilt_cohortAC1_cases	0.64	2.06	4.12	1.11	10.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_cases	AD-Familial	0.00	-0.60	0.98	0.05	4.54
AD-Familial	ADSP_10K_UKBaltfilt_cohortAC1_cases	0.03	1.49	4.41	1.59	9.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_10K_UKBaltfilt_cohortAC1_cases	404	402	TFDP2;PNLIPRP2
AD-Familial	14	14