Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	AD-GWAS	9.84e-02	8.51e-02	3.68e-04	1.78e-04
AD-GWAS Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_cases	9.64e-05	1.44e-02	2.53e-06	1.73e-17
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	AD-GWAS Exclusive	9.97e-02	1.14e-01	1.33e-03	2.20e-04
AD-GWAS Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	9.28e-05	3.99e-02	7.48e-07	1.08e-17
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.25e-01
AD-GWAS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	7.94e-39	1.94e-17	4.01e-87	1.12e-36



Evaluating how well ADSP_10K_UKBaltfilt_cohortAC1_cases genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	AD-GWAS	0.73	1.61	2.78	1.70	4.01
AD-GWAS Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_cases	0.63	0.56	3.75	1.06	8.57
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	AD-GWAS Exclusive	0.72	1.50	1.95	1.27	3.88
AD-GWAS Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	0.63	0.61	3.14	1.02	9.15
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	Overlap	0.97	1.50	1.19	1.16	1.64
AD-GWAS Exclusive	Overlap	1.00	1.62	1.53	1.63	1.67
Overlap	Exclusives	0.71	2.89	10.21	2.07	14.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	AD-GWAS	0.00	0.75	2.22	1.02	1.42
AD-GWAS Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_cases	0.03	1.17	5.90	2.28	10.37
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	AD-GWAS Exclusive	0.00	0.40	1.20	0.96	3.02
AD-GWAS Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	0.03	1.21	4.54	1.80	10.20
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	Overlap	0.00	2.27	2.27	0.62	0.35
AD-GWAS Exclusive	Overlap	0.03	81.02	41.42	121.08	3.40
Overlap	Exclusives	0.05	4.02	19.71	2.53	23.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_10K_UKBaltfilt_cohortAC1_cases Exclusive	403	401	PNLIPRP2;TFDP2
AD-GWAS Exclusive	24	23	HLA -DRB1
Overlap	1	1