Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	AD-Familial	2.84e-01	1.41e-01	2.50e-02	1.23e-04
AD-Familial	ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	6.30e-04	1.49e-02	2.39e-16	1.62e-14



Evaluating how well ADSP_10Kclean_UKBaltfilt_cohortAC1_cases genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	AD-Familial	0.79	1.98	1.78	1.37	4.25
AD-Familial	ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	0.63	0.93	2.62	0.72	9.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	AD-Familial	0.00	-1.02	-0.50	-0.45	1.53
AD-Familial	ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	0.03	-0.08	2.61	0.89	7.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	394	393	UGT2A1
AD-Familial	14	14