Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	AD-GWAS	4.21e-01	2.94e-01	5.94e-03	1.29e-03
AD-GWAS	ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	2.75e-07	2.74e-01	7.20e-04	1.70e-14



Evaluating how well ADSP_10Kclean_UKBaltfilt_cohortAC1_cases genes are linked to AD-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	AD-GWAS	0.69	0.49	1.40	0.67	3.11
AD-GWAS	ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	0.61	-0.01	1.70	0.35	8.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	AD-GWAS	0.00	-0.58	0.15	0.09	1.55
AD-GWAS	ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	0.03	0.19	2.57	0.95	7.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_10Kclean_UKBaltfilt_cohortAC1_cases	394	393	UGT2A1
AD-GWAS	25	24	HLA -DRB1