Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	AD-Familial	6.73e-03	1.86e-02	3.19e-06	9.62e-07
AD-Familial Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_controls	7.83e-05	8.34e-03	2.45e-19	2.36e-21
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	AD-Familial Exclusive	1.99e-03	4.33e-03	3.66e-06	9.35e-06
AD-Familial Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	8.59e-06	4.49e-03	4.60e-20	3.49e-22
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	Overlap	6.74e-01	5.40e-01	1.66e-01	8.69e-02
AD-Familial Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	1.59e-16	3.11e-02	2.45e-100	5.36e-23



Evaluating how well ADSP_10K_UKBaltfilt_cohortAC1_controls genes are linked to AD-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	AD-Familial	0.86	2.50	3.06	2.09	5.62
AD-Familial Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_controls	0.65	1.85	4.48	1.12	10.70
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	AD-Familial Exclusive	0.85	2.70	3.80	2.44	4.51
AD-Familial Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	0.65	1.68	4.03	0.92	10.36
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	Overlap	0.88	0.18	0.72	0.92	1.75
AD-Familial Exclusive	Overlap	1.00	3.73	3.39	2.83	2.69
Overlap	Exclusives	0.66	4.47	3.46	1.12	11.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	AD-Familial	0.00	0.06	2.62	0.45	1.11
AD-Familial Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_controls	0.03	2.11	6.29	2.01	9.75
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	AD-Familial Exclusive	0.00	0.26	2.52	0.54	0.89
AD-Familial Exclusive	ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	0.03	2.00	4.88	1.67	12.01
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	Overlap	0.00	-0.83	0.81	-0.14	0.34
AD-Familial Exclusive	Overlap	0.01	89.47	55.58	40.77	28.38
Overlap	Exclusives	0.04	5.49	4.55	1.12	14.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP_10K_UKBaltfilt_cohortAC1_controls Exclusive	406	404	UGT2A1;PTPN20
AD-Familial Exclusive	12	12	
Overlap	2	2