Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_10K_clean4 Exclusive	25GS	9.94e-03	5.22e-03	1.22e-02	2.07e-05
25GS Exclusive	EAML_10K_clean4	1.27e-01	1.64e-03	2.51e-05	4.58e-03
EAML_10K_clean4 Exclusive	25GS Exclusive	9.22e-03	2.27e-03	1.39e-02	1.14e-04
25GS Exclusive	EAML_10K_clean4 Exclusive	1.60e-01	1.80e-03	1.79e-05	5.42e-03
EAML_10K_clean4 Exclusive	Overlap	8.51e-01	5.40e-01	9.82e-01	9.41e-02
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	4.92e-02	2.42e-03	1.67e-34	1.91e-03



Evaluating how well EAML_10K_clean4 genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean4 Exclusive	25GS	0.71	1.63	2.21	1.54	4.20
25GS Exclusive	EAML_10K_clean4	0.56	2.28	2.73	2.43	2.39
EAML_10K_clean4 Exclusive	25GS Exclusive	0.70	1.68	2.39	1.24	2.91
25GS Exclusive	EAML_10K_clean4 Exclusive	0.55	2.54	2.55	2.33	1.91
EAML_10K_clean4 Exclusive	Overlap	0.85	0.76	0.59	0.56	1.68
25GS Exclusive	Overlap	1.00	2.62	2.55	2.95	2.40
Overlap	Exclusives	0.61	3.41	5.14	2.30	4.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean4 Exclusive	25GS	0.00	0.65	0.95	0.57	1.96
25GS Exclusive	EAML_10K_clean4	0.01	3.61	1.65	2.75	2.70
EAML_10K_clean4 Exclusive	25GS Exclusive	0.00	0.52	1.05	0.11	0.63
25GS Exclusive	EAML_10K_clean4 Exclusive	0.01	1.12	0.23	0.51	0.39
EAML_10K_clean4 Exclusive	Overlap	0.00	-0.02	-3.82	-0.30	0.69
25GS Exclusive	Overlap	0.04	86.09	208.67	144.64	2.70
Overlap	Exclusives	0.04	48.41	62.32	25.77	49.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_10K_clean4 Exclusive	116	112	;TNFSF12-TNFSF13;RFPL2;AC131097.2
25GS Exclusive	23	22	HLA -DRB1
Overlap	2	2