Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_10K_clean5 Exclusive	25GS	2.66e-01	4.15e-01	9.05e-01	3.77e-02
25GS Exclusive	EAML_10K_clean5	4.60e-01	1.29e-01	1.90e-02	3.07e-01
EAML_10K_clean5 Exclusive	25GS Exclusive	4.54e-01	4.25e-01	7.89e-01	1.43e-01
25GS Exclusive	EAML_10K_clean5 Exclusive	3.29e-01	1.32e-01	3.20e-02	3.22e-01
EAML_10K_clean5 Exclusive	Overlap	2.42e-01	5.40e-01	6.47e-01	7.39e-02
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	7.26e-03	7.62e-04	6.85e-22	1.09e-03



Evaluating how well EAML_10K_clean5 genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean5 Exclusive	25GS	0.61	0.68	0.44	0.02	1.72
25GS Exclusive	EAML_10K_clean5	0.52	1.34	1.39	1.12	0.80
EAML_10K_clean5 Exclusive	25GS Exclusive	0.59	0.25	0.30	-0.07	1.41
25GS Exclusive	EAML_10K_clean5 Exclusive	0.51	0.85	1.14	0.85	0.39
EAML_10K_clean5 Exclusive	Overlap	0.88	1.73	0.24	1.02	1.89
25GS Exclusive	Overlap	1.00	2.28	2.73	2.87	2.30
Overlap	Exclusives	0.61	3.22	4.77	2.64	3.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean5 Exclusive	25GS	0.00	0.32	-0.05	-0.23	0.25
25GS Exclusive	EAML_10K_clean5	0.01	2.63	2.91	1.68	1.67
EAML_10K_clean5 Exclusive	25GS Exclusive	0.00	-0.09	-0.05	-0.31	-0.02
25GS Exclusive	EAML_10K_clean5 Exclusive	0.00	-0.09	0.44	0.12	-0.17
EAML_10K_clean5 Exclusive	Overlap	0.00	1.69	0.99	1.39	0.05
25GS Exclusive	Overlap	0.04	113.16	229.65	153.68	54.49
Overlap	Exclusives	0.05	108.67	92.33	45.23	79.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_10K_clean5 Exclusive	82	77	;PRAMEF11;TNFSF12-TNFSF13;RFPL2;AL162417.1
25GS Exclusive	23	22	HLA -DRB1
Overlap	2	2