Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_10K_clean5 Exclusive	25GS	4.58e-06	1.32e-06	7.13e-06	2.37e-08
25GS Exclusive	EAML_10K_clean5	4.86e-01	7.40e-02	3.87e-03	3.46e-02
EAML_10K_clean5 Exclusive	25GS Exclusive	9.74e-06	3.01e-06	4.93e-06	4.63e-07
25GS Exclusive	EAML_10K_clean5 Exclusive	6.24e-01	6.08e-02	5.09e-04	6.05e-02
EAML_10K_clean5 Exclusive	Overlap	1.60e-01	5.40e-01	3.12e-01	2.67e-02
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.93e-02	3.50e-03	7.36e-31	3.92e-03



Evaluating how well EAML_10K_clean5 genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean5 Exclusive	25GS	0.85	3.22	6.18	3.10	6.62
25GS Exclusive	EAML_10K_clean5	0.54	2.08	1.76	1.55	1.65
EAML_10K_clean5 Exclusive	25GS Exclusive	0.84	3.74	5.68	4.50	5.77
25GS Exclusive	EAML_10K_clean5 Exclusive	0.54	1.67	1.43	1.70	1.65
EAML_10K_clean5 Exclusive	Overlap	0.95	1.61	0.91	1.35	2.06
25GS Exclusive	Overlap	1.00	2.72	2.21	2.66	2.32
Overlap	Exclusives	0.60	1.32	4.72	2.32	4.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean5 Exclusive	25GS	0.01	7.30	13.86	5.92	11.55
25GS Exclusive	EAML_10K_clean5	0.01	6.88	4.56	5.31	9.29
EAML_10K_clean5 Exclusive	25GS Exclusive	0.01	7.99	11.89	0.82	4.78
25GS Exclusive	EAML_10K_clean5 Exclusive	0.01	6.65	3.06	3.36	5.52
EAML_10K_clean5 Exclusive	Overlap	0.00	3.69	2.17	2.79	2.01
25GS Exclusive	Overlap	0.04	62.82	184.63	185.73	133.20
Overlap	Exclusives	0.05	60.13	76.93	36.14	44.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_10K_clean5 Exclusive	128	123	;TNFSF12-TNFSF13;AL162417.1;PRAMEF11;RFPL2
25GS Exclusive	23	22	HLA -DRB1
Overlap	2	2