Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_10K_clean3 Exclusive	25GS	3.77e-06	4.77e-06	3.67e-05	2.34e-09
25GS Exclusive	EAML_10K_clean3	1.12e-01	1.23e-01	3.45e-03	4.47e-02
EAML_10K_clean3 Exclusive	25GS Exclusive	5.39e-06	1.59e-06	3.52e-05	3.29e-08
25GS Exclusive	EAML_10K_clean3 Exclusive	2.29e-01	8.47e-02	1.87e-03	1.02e-01
EAML_10K_clean3 Exclusive	Overlap	6.52e-02	5.40e-01	1.10e-01	2.32e-02
25GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	5.85e-02	3.74e-03	3.68e-33	3.26e-03



Evaluating how well EAML_10K_clean3 genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean3 Exclusive	25GS	0.85	3.33	6.21	3.31	5.74
25GS Exclusive	EAML_10K_clean3	0.56	2.34	1.94	2.24	2.51
EAML_10K_clean3 Exclusive	25GS Exclusive	0.84	3.68	6.38	2.80	5.52
25GS Exclusive	EAML_10K_clean3 Exclusive	0.55	1.91	1.74	2.13	1.98
EAML_10K_clean3 Exclusive	Overlap	0.96	2.07	0.76	1.55	2.27
25GS Exclusive	Overlap	1.00	2.39	2.69	2.46	2.23
Overlap	Exclusives	0.59	1.82	4.45	2.25	4.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_10K_clean3 Exclusive	25GS	0.01	4.85	11.97	4.38	3.35
25GS Exclusive	EAML_10K_clean3	0.01	8.93	3.67	6.34	7.78
EAML_10K_clean3 Exclusive	25GS Exclusive	0.00	6.47	14.62	1.88	2.53
25GS Exclusive	EAML_10K_clean3 Exclusive	0.01	5.11	2.83	4.06	2.55
EAML_10K_clean3 Exclusive	Overlap	0.00	2.42	-2.25	1.79	4.78
25GS Exclusive	Overlap	0.04	63.29	228.29	185.92	48.24
Overlap	Exclusives	0.05	56.20	78.81	28.90	39.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_10K_clean3 Exclusive	128	123	;PRAMEF11;AL162417.1;RFPL2;TNFSF12-TNFSF13
25GS Exclusive	23	22	HLA -DRB1
Overlap	2	2